Fri Jun 20 2025

123 articles - From Friday Jun 13 2025 to Friday Jun 20 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Systematic Review: Variability in Definitions of Fibrostenosis in Eosinophilic Oesophagitis.

Significant variability exists in definitions and diagnostic methods of detection regarding fibrostenosis in eosinophilic oesophagitis. Lack of agreement hampers progress in further investigating this complication. Development of consensus criteria is necessary to provide clarity for clinical care and research.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Pharmacological Strategies for the Management of Severe Alcohol-associated Hepatitis: A Systematic Review and Meta-analysis.

Low certainty evidence supports the efficacy of corticosteroids as first line therapy for eligible patients with severe AH. The certainty of the evidence supporting other therapies ranges from low to moderate. Further studies are needed to confirm these benefits.

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Yield of Advanced Neoplasia at 2<sup>nd</sup> Post-Polypectomy Surveillance Colonoscopy: A Systematic Review and Meta-Analysis.

These findings support the concept of using results from both the baseline and 1 st surveillance colonoscopies to provide a more accurate risk estimate than using results of only the most recent colonoscopy.

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Gastrointest Endosc

Efficacy and Safety of Repeat Endoscopic Submucosal Dissection for Recurrent, Synchronous, and Metachronous Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

Repeat ESD demonstrated acceptable clinical outcomes for recurrent ESCC. Despite technical challenges and variability in complications, it seems to be a viable endoscopic option, emphasizing the need for further research to optimize outcomes.

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Local recurrence rates of horizontal margin-positive en bloc endoscopic submucosal dissection of colorectal neoplasia: a meta-analysis.

En bloc ESD with HM1/x margins is associated with a significantly higher risk of local recurrence compared to HM0 resection. However, the absolute risk remains low and most recurrences are benign. As invasive recurrences seem to originate from initially invasive or HGD lesions, intensive surveillance should be prioritized for HM1/x cases with these characteristics, rather than al HM1/x cases.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Azathioprine or Tofacitinib as Maintenance Therapy in Corticosteroid-Responsive Acute Severe Ulcerative Colitis.

Tofacitinib is more effective than azathioprine as maintenance therapy for steroid-responsive ASUC at 1 year.

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Optimising Use of Stool Gluten Immunogenic Peptide Tests for Monitoring Adherence to Gluten-Free Diet in Patients With Coeliac Disease.

Testing stool twice within 7 days was practical and accurate for monitoring dietary adherence. This approach effectively balances patient convenience with diagnostic accuracy for routine clinical use.

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Safety and Tolerability of Injectable Extended-Release Naltrexone for the Management of Alcohol Use Disorder in Advanced Alcohol-Associated Liver Disease.

In this case series, XR-NTX was well tolerated in patients with advanced ALD, without evidence of hepatotoxicity or liver decompensation.

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Surviving Hepatitis C-Understanding Death and Survival Beyond Cure.

Liver-related death drives mortality for cirrhotic patients. Curing HCV remains critical. Holistic HCV care, with attention to mental health illnesses in younger patients, metabolic comorbidities, and better cancer screening for older patients may reduce excess mortality.

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Twenty-Year Trends in Colectomy Rates and Advanced Therapy Prescribing in Lothian, Scotland.

The incidence of colectomy in the UC population has decreased over time while the use of advanced therapies has greatly increased.

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Am J Gastroenterol

DRESS syndrome in patients with drug-induced liver injury: Characteristics and HLA risk factors.

Patients with DILI and DRESS are younger, more likely to be Black, had shorter time to DILI onset with more severe liver injury and higher overall and liver-related mortality. HLA A*32 01, HLA B*53 01 and HLA B*58 01 are risk factors for DILI-DRESS.

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Dissatisfaction and Barriers in Electronic Health Record Use for Inflammatory Bowel Disease Patients: A Nationwide Survey of Major IBD Centers.

This is the first IBD program survey in the United States showing significant dissatisfaction and opportunity for EHR enhancements to improve patient care.

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Dupilumab Efficacy in Children With Eosinophilic Esophagitis With Prior Swallowed Topical Corticosteroid Use: A Subgroup Analysis.

Dupilumab may be an effective treatment in children with EoE with prior STC use, or prior IRIC to STCs.

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Increasing Prevalence of Cannabinoid Hyperemesis Syndrome in Young Adults and Minority Populations.

Younger adults, Hispanic individuals and Black individuals may be at higher risk for presenting with CHS.

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Trends in Underrepresented Fellows in Gastroenterology.

Efforts to promote a more inclusive workforce in GI have had limited success over the past decade. Successful interventions that institutions can implement include supporting minority applicants, structured mentorship, and bias mitigation training.

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Clin Gastroenterol Hepatol

ALT is an effective screening tool for advanced MASLD in children with obesity and overweight.

This study shows that ALT is an effective primary screening step for increased liver stiffness, suggestive of significant fibrosis, in children with obesity or overweight and additional risk factors.

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Intestinal Ultrasound and Its Advanced Modalities in Characterizing Strictures in Crohn's Disease.

A combination of IUS and CEUS is accurate to differentiate between inflammatory and chronic strictures in CD. The SSA needs external validation and confirmation in its potential as a diagnostic decision aid when choosing between surgical and available medical treatments.

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Janus kinase (JAK) inhibitor-induced acne in inflammatory bowel disease - an international, multicenter, retrospective cohort study.

This is the first study characterizing this adverse event in JAK inhibitor-treated IBD patients and presents the largest cohort of JAK inhibitor-induced acne cases across al immune-mediated diseases. Acne is a common adverse effect resulting in significant psychological burden. Early identification, proactive counseling, and timely interventions, such as dose reduction or referral to dermatology, are crucial in managing this side effect.

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NAVIGATING THE MAZE OF FUNCTIONAL DYSPEPSIA: EMERGENCE OF A NEW ENTITY, POSTPRANDIAL EPIGASTRIC PAIN SYNDROME.

In contrast to earlier characterization of EPS symptoms as purely meal-unrelated, we identified a relevant patient cohort with postprandial epigastric pain in the absence of PDS symptoms in 4 different cohorts. Further research is needed to determine the underlying pathophysiology, and the response to different treatment approaches in these newly defined patient cohorts.

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Perianal Disease in Pediatric-Onset Crohn's Disease: Incidence, Disease Course, and Long-Term Outcomes.

We report a high incidence of perianal disease in pediatric-onset CD. Patients with perianal disease had higher risks of major abdominal surgery and requiring stomas than patients without perianal CD.

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Psychomotor development in infants following maternal exposure to biologics: Results from the DUMBO registry.

Exposure to biologics for IBD in utero or during breastfeeding has no negative impact on psychomotor development in infants.

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Endoscopy

Aggressive versus Conservative Endotherapy for Gastric Varices in Cirrhosis: A Randomized Controlled Trial.

Aggressive endotherapy resulted in similar rebleeding and mortality rates compared to conservative therapy.

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Clinical decision tree for optimising endoscopic assessment of signet ring cell carcinoma in hereditary diffuse gastric cancer surveillance.

We developed and validated a practical endoscopic framework to enhance SRCC assessment during HDGC endoscopic surveillance.

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Gastroenterology

Association Between Adenoma Detection Rate and Prevalent Colorectal Cancer Detection Rate in a National Colonoscopy Registry Subtitle: Association Between Adenoma and Colorectal Cancer Detection.

ADR reflects prevalent CRC detection as well as detection and removal of CRC precursors. Our findings suggest that PCCRC is not uncommonly due to missed CRC, especially among endoscopists with low ADR.

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Total Pancreatectomy and Islet Auto Transplant for Chronic Pancreatitis.

In this prospective multicenter study of patients with intractably painful CP or RAP, TPIAT significantly reduced pain burden and improved QOL. While young age predicted better outcomes, duration and etiology of disease did not.

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Gastrointest Endosc

Comparison of survival and recurrence between colonic and rectal tumors after resection in T1 colorectal cancer: long-term cohort study.

T1 rectal cancer had a worse prognosis than T1 colonic cancer after high-risk lesion SR. Careful surveillance is required for high-risk T1 rectal cancers with venous invasion or a high BD.

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Preliminary feasibility study of a novel spiral-designed plastic stent for endoscopic management of malignant hilar biliary obstruction: a multicenter prospective study (with videos).

The newly designed Twist plastic stent exhibited high technical success and sustained patency in with the management of MHO, with a 3-month stent patency rate of 76.9% and no observed instances of spontaneous migration. These findings highlight its potential role in optimizing biliary drainage.

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Safety and Efficacy of Margin and Base Ablation After Endoscopic Mucosal Resection of Large Nonpedunculated Colorectal Polyps: A Prospective Multi-Center Study.

In a prospective multicenter study, EMR with systematic ablation of the complete post-resection base and visible vessels in addition to margin ablation demonstrated high technical success, low adverse events and low recurrences. A randomized controlled trial is needed to compare the safety and efficacy of systematic base and margin ablation to margin ablation only.

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Gut

A fusion-based deep-learning algorithm predicts PDAC metastasis based on primary tumour CT images: a multinational study.

This study represents a pioneering utilisation of a high-performance deep-learning model to predict extrapancreatic organ metastasis in patients with PDAC.

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Hepatology

Antiangiogenic therapy combined with immune checkpoint blockade mediates CCR7+CD8+ T-cell entry into HCC through high endothelial venules.

HEVs are pivotal in modulating immune activity within the HCC tumor microenvironment. Targeting the VEGFC-NF-κB (non- canonical)-HEV axis could be a promising therapeutic strategy to enhance antitumor immunity and improve outcomes in patients with HCC who are receiving combination AAD plus ICB therapy.

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Refinement of histologic subtypes and identification of biomarkers linked to unfavorable prognosis in cholangiocarcinoma: The ENSCCA registries' framework for digital twin advancement.

Our data underline the importance of identifying morphological subclasses with a significant prevalence in CCA as a tool for risk stratification and prognosis. The European CCA Histology Registry represents a valuable platform for integrating digital pathology with clinical, radiological, and molecular information as a framework for digital twin advancement.

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J Hepatol

Clinical utility of phosphatidylethanol to detect underreported alcohol use and enhance steatotic liver disease subclassification.

PEth may objectively quantify alcohol use and help identify SLD subcategories alongside clinical history, mitigating diagnostic misclassification. Impact and implications The current subclassification of steatotic liver disease (SLD) relies on self-reported alcohol use, which is frequently limited by patient underreporting, potentially leading to diagnostic misclassification. In this study of 391 community-dwelling adults with overweight/obesity and SLD assessed by advanced MRI methods, we found that 15.9% (95% CI 12.2%-19.5%) of individuals with SLD underreported alcohol use based on their phosphatidylethanol (PEth) levels. Male gender, absence of type 2 diabetes, and White race were the strongest independent factors associated with alcohol underreporting in this population. The incorporation of PEth alongside self-reported alcohol use resulted in a 4-fold increase in MetALD diagnoses and a 3-fold increase in ALD diagnoses. These findings support the clinical utility of PEth as a direct, quantitative, objective alcohol biomarker which may help clinicians identify SLD subcategories and differentiate between its metabolic and alcohol-related etiologies.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: Endomysial Antibodies for a No-Biopsy Diagnosis of Coeliac Disease-The Jury Is Still Out.

Pubmed   Journal   ReadQx 

Editorial: Patient Reported Outcomes Provide Insight Into Disease Severity for People Living With Primary Sclerosing Cholangitis.

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Editorial: Shooting in the Dark-The Problem With Empiric Antispasmodics for Abdominal Pain in Inflammatory Bowel Disease.

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Review: Human Intestinal Barrier-Optimal Measurement and Effects of Diet in the Absence of Overt Inflammation or Ulceration.

Currently, data are not exclusively from human studies, and research is needed to corroborate observations in animals or further validate in humans. There are several practical dietary approaches that can be instituted for restoration of the intestinal barrier in humans.

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Gastroenterology

Senescence, aging and disease throughout the gastrointestinal system.

In this review we describe the mechanisms, hallmarks and consequences of cellular senescence, as well as the therapeutic potential of senescence-targeting interventions. We aim to highlight the importance of understanding the molecular basis of senescence in gastroenterology, whilst connecting the worlds of research and clinical practice.

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Gastrointest Endosc

Current-generation sequencing: Has the next generation of malignant biliary stricture identification arrived?

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Endoscopic retrograde cholangiopancreatography-related duodenal perforations in the modern era of advanced endoscopy.

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Pancreatic endotherapy and quality of life in chronic pancreatitis.

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J Hepatol

Sour taste sensation as a neuroimmune modulator in liver injury.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

All Aboard the All-Exam Adenoma Detection Rate.

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Letter to the Editor.

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Letter to the Editor.

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Letter to the Editor.

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Response to Macias et al.

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Response to Sah et al.

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Response to Zhang and Fang.

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Unresolved Challenges in MAFLD-ACLF Risk Stratification: A Critical Appraisal.

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Clin Gastroenterol Hepatol

Addition of AFP Improves Sensitivity of Ultrasound for Early-Stage HCC Detection in Patients with Cirrhosis.

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Stable Trends in Incidence of Young-Onset Esophageal Adenocarcinoma: A Twenty-Year Analysis from the United States Cancer Statistics Database.

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Endoscopy

A case of annular pancreas complicated with pancreatic ductal adenocarcinoma diagnosed with linear endoscopic ultrasound.

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A new method of intra-small intestinal ultrasonography using double-balloon enteroscopy.

Pubmed   Journal   ReadQx   PMC

A novel endoscopic approach for efficient and safe resection of tumors at the appendiceal orifice.

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A novel multipoint mucosal bridge technique in endoscopic submucosal tunneling dissection for esophageal lesions.

Pubmed   Journal   ReadQx   PMC

A novel underwater endoscopic submucosal dissection via continuous irrigation method for esophageal squamous cell carcinoma with severe fibrosis.

Pubmed   Journal   ReadQx   PMC

An Y shaped tunnel to bypass a hemorrhoid band ligation scar during rectal endoscopic submucosal dissection.

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Antireflux mucosal intervention for refractory gastroesophageal reflux disease after multiple Nissen fundoplications.

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Combined endoscopic approach with fluoroscopy-guided radial incision and cutting for a complete esophageal stricture.

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Confocal endomicroscopy: an additional approach in the watch-and-wait strategy for advanced rectal tumors.

Pubmed   Journal   ReadQx   PMC

Confocal endoscopy-assisted diagnosis of duodenal follicular lymphoma: a rare case report.

Pubmed   Journal   ReadQx   PMC

Cryoablation for Barrett's esophagus with dysplasia and eosinophilic esophagitis: A novel approach for a rare dual condition.

Pubmed   Journal   ReadQx   PMC

Endoscopic direct-vision appendicitis therapy for the treatment of chronic appendicitis with multiple appendicoliths.

Pubmed   Journal   ReadQx 

Endoscopic submucosal dissection of early gastric cancer in the gastric fundus: challenges and techniques.

Pubmed   Journal   ReadQx   PMC

Endoscopic ultrasonography-guided choledochoduodenostomy without tract dilation using a novel ultra-tapered slim-delivery metallic stent.

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Endoscopic ultrasonography-guided hepaticogastrostomy with a novel 0.018-inch guidewire and a slim-delivery metallic stent.

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Endoscopic ultrasound-directed transenteric retrograde cholangiopancreatography using a new slim scope with an operative working channel.

Pubmed   Journal   ReadQx   PMC

Endoscopic ultrasound-guided choledochoduodenostomy using lumen-apposing metal stents: a call for standardized training, rescue management, and revision of stent design.

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Endoscopic virtual ruler based on artificial intelligence technology.

Pubmed   Journal   ReadQx   PMC

Hepatic flexure breakdown strategy with adaptive traction for endoscopic submucosal dissection.

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Intrachannel anterograde snare traction combined with a clip-and-line system for polyps in the appendix cavity.

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Intrahepatic bile duct stone removal using a tapered-tip sheath system.

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Is endoscopic radiofrequency ablation safe and effective for treating rare neuroendocrine tumors of the minor papilla?

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Necrosectomy performed by a single-use endoscope with a large operative working channel.

Pubmed   Journal   ReadQx   PMC

Novel biopsy forceps removed pancreatic duct foreign bodies in disconnected pancreatic duct syndrome via endoscopic ultrasound-guided pancreatic duct drainage fistula.

Pubmed   Journal   ReadQx   PMC

Novel combination closure of an artificial ulcer after gastric endoscopic submucosal dissection using a double-arm-bar suturing system and an anchor prong clip.

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Reverse sphincterotomy assisted accessory pancreatic duct cannulation.

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Salvage endoscopic intermuscular dissection: curative treatment for residual rectal adenocarcinoma after chemoradiotherapy.

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Shallow endoscopic submucosal dissection using a gas-free immersion system to prevent strictures after esophageal dissections.

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Subsequent ileal stent placement for synchronous small-bowel obstruction through endoscopic ultrasound-guided ileocolostomy with a lumen-apposing metal stent.

Pubmed   Journal   ReadQx   PMC

The endoscopist's third hand: external floss traction-assisted duodenal papillary intubation for hidden papilla.

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Two-devices-in-one-channel method using biopsy forceps for ultrasonography-guided hepaticogastrostomy reintervention.

Pubmed   Journal   ReadQx   PMC

Uncommon complications arising during endoscopic ultrasound-guided gastroenterostomy - splenic injury.

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Underwater endoscopic resection for flat lesions in the stomach often results in immediate bleeding?

Pubmed   Journal   ReadQx 

Underwater endoscopic submucosal dissection of a 20-cm-long circular rectosigmoid polyp.

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Underwater endoscopic submucosal dissection with gel immersion and red dichromatic imaging for an anastomotic lesion following colon surgery.

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Gastroenterology

A Curious Culprit Behind Biliary Pus: What's the Diagnosis?

Pubmed   Journal   ReadQx 

Evaluating Disparities in Recurrent Clostridioides difficile Infection (CDI) and Fecal Microbiota Transplant (FMT) Treatment using Geospatial and Social Vulnerability Analytic Tools.

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Leveraging Professional Networking For Career Advancement - Tips for Early Career Faculty.

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Spatial transcriptomics of Hirschsprung disease resection margins marks differential gene expression in myenteric plexus.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

A Case of Post-Covid-19 Cholangiopathy with Large Biliary Cast Removal.

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A rare case of urachal cyst in the ascending colon of an adult patient.

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IgG4-related colonic submucosal lesion.

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Pseudoachalasia secondary to esophageal amyloidosis.

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Unusual Submucosal Mass with Cystic Features Revealed by EUS: A Case of Gastric Adenocarcinoma of the Fundic Gland Type.

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Gut

Dangerous intestinal disease: a case of recurrent abdominal pain with lower gastrointestinal bleeding.

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NLRP6 deficiency enhances macrophage-mediated phagocytosis via E-Syt1 to inhibit hepatocellular carcinoma progression.

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Retraction: Unleashing the potential of exosome ncRNAs for early gastric cancer detection-a critical appraisal of machine learning approaches.

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Hepatology

Building hepatitis B virus gene transcription from the bottom up.

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Genes that fit just right: Unzipping the genome of fatty liver disease.

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Letter to editor: Considerations on the specific role of LHX2 in the process of hepatic stellate cells regulating hepatocyte function.

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Not so subclinical: Is early thyroid disease an untapped avenue to protect children from MASLD?

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Reply: Considerations on the specific role of LHX2 in the process of hepatic stellate cells regulating hepatocyte function.

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Retraction: GABA induces the differentiation of small into large cholangiocytes by activation of Ca2+/CaMK I-dependent adenylyl cyclase 8.

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Retraction: α-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca2+- and PKC-dependent stimulation of cAMP.

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The dynamic duo: How tumor-associated macrophages and tumor cells team up in cholangiocarcinoma.

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Two heads are better than one: The synergy of carvedilol and simvastatin.

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J Hepatol

Dysphagia associated with portal hypertension and hepatocellular carcinoma, singular coincidence or hidden pathway?

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From the Editor's Desk….

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Sympathetic activation of adipose tissue lipolysis underlies overnutrition-induced metabolic dysfunction.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: Endomysial Antibodies for a No-Biopsy Diagnosis of Coeliac Disease-The Jury Is Still out. Authors' Reply.

Pubmed   Journal   ReadQx 

Letter: Methodological Gaps Undermine Conclusions on Electronic Nose Use for Colorectal Cancer Detection-Authors' Reply.

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Letter: Methodological Gaps Undermine Conclusions on Electronic Nose Use for Colorectal Cancer Detection.

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Gastroenterology

Comments on "Multi-HCC: A Practical Model to Prioritize Patients With Hepatocellular Carcinoma on the Liver Transplant Waiting List".

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Glepaglutide in Short Bowel Syndrome: Promising, but Questions Remain.

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Optimizing the Multi-HCC Model: Implications for Clinical Decision-Making and Transplant Prioritization.

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Personalized Dosing Strategies: The Missing Link in Glepaglutide Therapy for Short Bowel Syndrome.

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Potential and challenges of glepaglutide for SBS-IF.

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Refining Multi-HCC for Balanced Urgency and Utility.

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Gastrointest Endosc

"One and done": a new piece of evidence from China.

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Gut

Enhancing non-invasive early detection of gastric cancer: a critical reflection on exosome ncRNA and machine learning.

Pubmed   Journal   ReadQx 

Validation of the CLIF-SIG score in patients with HBV-related acutely decompensated cirrhosis.

Pubmed   Journal   ReadQx 

J Hepatol

Response to Picchio et al.: Re: Moving Diagnosis of Liver Fibrosis into the Community.

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