123 articles - From Friday Jun 13 2025 to Friday Jun 20 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
|---|
Systematic Review: Variability in Definitions of Fibrostenosis in Eosinophilic Oesophagitis. Significant variability exists in definitions and diagnostic methods of detection regarding fibrostenosis in eosinophilic oesophagitis. Lack of agreement hampers progress in further investigating this complication. Development of consensus criteria is necessary to provide clarity for clinical care and research. |
| Clin Gastroenterol Hepatol |
Pharmacological Strategies for the Management of Severe Alcohol-associated Hepatitis: A Systematic Review and Meta-analysis. Low certainty evidence supports the efficacy of corticosteroids as first line therapy for eligible patients with severe AH. The certainty of the evidence supporting other therapies ranges from low to moderate. Further studies are needed to confirm these benefits. |
Yield of Advanced Neoplasia at 2<sup>nd</sup> Post-Polypectomy Surveillance Colonoscopy: A Systematic Review and Meta-Analysis. These findings support the concept of using results from both the baseline and 1 st surveillance colonoscopies to provide a more accurate risk estimate than using results of only the most recent colonoscopy. |
| Gastrointest Endosc |
Efficacy and Safety of Repeat Endoscopic Submucosal Dissection for Recurrent, Synchronous, and Metachronous Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. Repeat ESD demonstrated acceptable clinical outcomes for recurrent ESCC. Despite technical challenges and variability in complications, it seems to be a viable endoscopic option, emphasizing the need for further research to optimize outcomes. |
Local recurrence rates of horizontal margin-positive en bloc endoscopic submucosal dissection of colorectal neoplasia: a meta-analysis. En bloc ESD with HM1/x margins is associated with a significantly higher risk of local recurrence compared to HM0 resection. However, the absolute risk remains low and most recurrences are benign. As invasive recurrences seem to originate from initially invasive or HGD lesions, intensive surveillance should be prioritized for HM1/x cases with these characteristics, rather than al HM1/x cases. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
Optimising Use of Stool Gluten Immunogenic Peptide Tests for Monitoring Adherence to Gluten-Free Diet in Patients With Coeliac Disease. Testing stool twice within 7 days was practical and accurate for monitoring dietary adherence. This approach effectively balances patient convenience with diagnostic accuracy for routine clinical use. |
Safety and Tolerability of Injectable Extended-Release Naltrexone for the Management of Alcohol Use Disorder in Advanced Alcohol-Associated Liver Disease. In this case series, XR-NTX was well tolerated in patients with advanced ALD, without evidence of hepatotoxicity or liver decompensation. |
Surviving Hepatitis C-Understanding Death and Survival Beyond Cure. Liver-related death drives mortality for cirrhotic patients. Curing HCV remains critical. Holistic HCV care, with attention to mental health illnesses in younger patients, metabolic comorbidities, and better cancer screening for older patients may reduce excess mortality. |
| Am J Gastroenterol |
DRESS syndrome in patients with drug-induced liver injury: Characteristics and HLA risk factors. Patients with DILI and DRESS are younger, more likely to be Black, had shorter time to DILI onset with more severe liver injury and higher overall and liver-related mortality. HLA A*32 01, HLA B*53 01 and HLA B*58 01 are risk factors for DILI-DRESS. |
Dissatisfaction and Barriers in Electronic Health Record Use for Inflammatory Bowel Disease Patients: A Nationwide Survey of Major IBD Centers. This is the first IBD program survey in the United States showing significant dissatisfaction and opportunity for EHR enhancements to improve patient care. |
Trends in Underrepresented Fellows in Gastroenterology. Efforts to promote a more inclusive workforce in GI have had limited success over the past decade. Successful interventions that institutions can implement include supporting minority applicants, structured mentorship, and bias mitigation training. |
| Clin Gastroenterol Hepatol |
ALT is an effective screening tool for advanced MASLD in children with obesity and overweight. This study shows that ALT is an effective primary screening step for increased liver stiffness, suggestive of significant fibrosis, in children with obesity or overweight and additional risk factors. |
Intestinal Ultrasound and Its Advanced Modalities in Characterizing Strictures in Crohn's Disease. A combination of IUS and CEUS is accurate to differentiate between inflammatory and chronic strictures in CD. The SSA needs external validation and confirmation in its potential as a diagnostic decision aid when choosing between surgical and available medical treatments. |
Janus kinase (JAK) inhibitor-induced acne in inflammatory bowel disease - an international, multicenter, retrospective cohort study. This is the first study characterizing this adverse event in JAK inhibitor-treated IBD patients and presents the largest cohort of JAK inhibitor-induced acne cases across al immune-mediated diseases. Acne is a common adverse effect resulting in significant psychological burden. Early identification, proactive counseling, and timely interventions, such as dose reduction or referral to dermatology, are crucial in managing this side effect. |
NAVIGATING THE MAZE OF FUNCTIONAL DYSPEPSIA: EMERGENCE OF A NEW ENTITY, POSTPRANDIAL EPIGASTRIC PAIN SYNDROME. In contrast to earlier characterization of EPS symptoms as purely meal-unrelated, we identified a relevant patient cohort with postprandial epigastric pain in the absence of PDS symptoms in 4 different cohorts. Further research is needed to determine the underlying pathophysiology, and the response to different treatment approaches in these newly defined patient cohorts. |
Perianal Disease in Pediatric-Onset Crohn's Disease: Incidence, Disease Course, and Long-Term Outcomes. We report a high incidence of perianal disease in pediatric-onset CD. Patients with perianal disease had higher risks of major abdominal surgery and requiring stomas than patients without perianal CD. |
| Endoscopy |
| Gastroenterology |
Association Between Adenoma Detection Rate and Prevalent Colorectal Cancer Detection Rate in a National Colonoscopy Registry Subtitle: Association Between Adenoma and Colorectal Cancer Detection. ADR reflects prevalent CRC detection as well as detection and removal of CRC precursors. Our findings suggest that PCCRC is not uncommonly due to missed CRC, especially among endoscopists with low ADR. |
Total Pancreatectomy and Islet Auto Transplant for Chronic Pancreatitis. In this prospective multicenter study of patients with intractably painful CP or RAP, TPIAT significantly reduced pain burden and improved QOL. While young age predicted better outcomes, duration and etiology of disease did not. |
| Gastrointest Endosc |
Comparison of survival and recurrence between colonic and rectal tumors after resection in T1 colorectal cancer: long-term cohort study. T1 rectal cancer had a worse prognosis than T1 colonic cancer after high-risk lesion SR. Careful surveillance is required for high-risk T1 rectal cancers with venous invasion or a high BD. |
Preliminary feasibility study of a novel spiral-designed plastic stent for endoscopic management of malignant hilar biliary obstruction: a multicenter prospective study (with videos). The newly designed Twist plastic stent exhibited high technical success and sustained patency in with the management of MHO, with a 3-month stent patency rate of 76.9% and no observed instances of spontaneous migration. These findings highlight its potential role in optimizing biliary drainage. |
Safety and Efficacy of Margin and Base Ablation After Endoscopic Mucosal Resection of Large Nonpedunculated Colorectal Polyps: A Prospective Multi-Center Study. In a prospective multicenter study, EMR with systematic ablation of the complete post-resection base and visible vessels in addition to margin ablation demonstrated high technical success, low adverse events and low recurrences. A randomized controlled trial is needed to compare the safety and efficacy of systematic base and margin ablation to margin ablation only. |
| Gut |
| Hepatology |
Antiangiogenic therapy combined with immune checkpoint blockade mediates CCR7+CD8+ T-cell entry into HCC through high endothelial venules. HEVs are pivotal in modulating immune activity within the HCC tumor microenvironment. Targeting the VEGFC-NF-κB (non- canonical)-HEV axis could be a promising therapeutic strategy to enhance antitumor immunity and improve outcomes in patients with HCC who are receiving combination AAD plus ICB therapy. |
Refinement of histologic subtypes and identification of biomarkers linked to unfavorable prognosis in cholangiocarcinoma: The ENSCCA registries' framework for digital twin advancement. Our data underline the importance of identifying morphological subclasses with a significant prevalence in CCA as a tool for risk stratification and prognosis. The European CCA Histology Registry represents a valuable platform for integrating digital pathology with clinical, radiological, and molecular information as a framework for digital twin advancement. |
| J Hepatol |
Clinical utility of phosphatidylethanol to detect underreported alcohol use and enhance steatotic liver disease subclassification. PEth may objectively quantify alcohol use and help identify SLD subcategories alongside clinical history, mitigating diagnostic misclassification. Impact and implications The current subclassification of steatotic liver disease (SLD) relies on self-reported alcohol use, which is frequently limited by patient underreporting, potentially leading to diagnostic misclassification. In this study of 391 community-dwelling adults with overweight/obesity and SLD assessed by advanced MRI methods, we found that 15.9% (95% CI 12.2%-19.5%) of individuals with SLD underreported alcohol use based on their phosphatidylethanol (PEth) levels. Male gender, absence of type 2 diabetes, and White race were the strongest independent factors associated with alcohol underreporting in this population. The incorporation of PEth alongside self-reported alcohol use resulted in a 4-fold increase in MetALD diagnoses and a 3-fold increase in ALD diagnoses. These findings support the clinical utility of PEth as a direct, quantitative, objective alcohol biomarker which may help clinicians identify SLD subcategories and differentiate between its metabolic and alcohol-related etiologies. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
Review: Human Intestinal Barrier-Optimal Measurement and Effects of Diet in the Absence of Overt Inflammation or Ulceration. Currently, data are not exclusively from human studies, and research is needed to corroborate observations in animals or further validate in humans. There are several practical dietary approaches that can be instituted for restoration of the intestinal barrier in humans. |
| Gastroenterology |
Senescence, aging and disease throughout the gastrointestinal system. In this review we describe the mechanisms, hallmarks and consequences of cellular senescence, as well as the therapeutic potential of senescence-targeting interventions. We aim to highlight the importance of understanding the molecular basis of senescence in gastroenterology, whilst connecting the worlds of research and clinical practice. |
| Gastrointest Endosc |
| J Hepatol |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| J Hepatol |